Table 4 |
||||
|
Adjusted association between serum and meconium biomarkers of tobacco smoke exposure and infant birth weight.* |
||||
|
N |
Mean Birth Weight |
Change in Birth Weight (95% CI) |
Confidence Limit Difference† |
|
|
|
||||
|
Meconium NIC |
||||
|
|
||||
|
Unexposed (< LOD) |
62 |
3386 |
Ref |
--- |
|
|
||||
|
SHS (LOD - 10 ng/g) |
212 |
3251 |
-136 (-295, 24) |
320 |
|
|
||||
|
Active (> 10 ng/g) |
28 |
3252 |
-135 (-395, 126) |
520 |
|
|
||||
|
Continuous† |
302 |
--- |
-62 (-178, 53) |
231 |
|
|
||||
|
Meconium COT |
||||
|
|
||||
|
Unexposed (< LOD) |
97 |
3317 |
Ref |
--- |
|
|
||||
|
SHS (LOD - 5 ng/g) |
171 |
3286 |
-27 (-175, 120) |
295 |
|
|
||||
|
Active (> 5 ng/g) |
34 |
3207 |
-106 (-348, 135) |
482 |
|
|
||||
|
Continuous† |
302 |
--- |
-61 (-132, 10) |
143 |
|
|
||||
|
Meconium 3HC |
||||
|
|
||||
|
Unexposed (< LOD) |
135 |
3335 |
Ref |
--- |
|
|
||||
|
SHS (LOD - 10 ng/g) |
139 |
3235 |
-100 (-246, 46) |
292 |
|
|
||||
|
Active (> 10 ng/g) |
28 |
3278 |
-57 (-307, 192) |
500 |
|
|
||||
|
Continuous† |
302 |
--- |
-30 (-96, 36) |
132 |
|
|
||||
|
Mean Serum COT |
||||
|
|
||||
|
Unexposed (< LOD) |
122 |
3377 |
Reference |
--- |
|
|
||||
|
SHS (LOD to 3 ng/mL) |
148 |
3265 |
-112 (-264, 41) |
305 |
|
|
||||
|
Active (> 3 ng/mL) |
32 |
3188 |
-189 (-462, 84) |
545 |
|
|
||||
|
Continuous† |
302 |
--- |
-60 (-135, 16) |
150 |
|
|
||||
|
16 Week Serum COT |
||||
|
|
||||
|
Unexposed (< LOD) |
101 |
3312 |
Reference |
--- |
|
|
||||
|
SHS (LOD to 3 ng/mL) |
162 |
3292 |
-20 (-173, 132) |
305 |
|
|
||||
|
Active (> 3 ng/mL) |
32 |
3203 |
-109 (-386, 168) |
554 |
|
|
||||
|
Continuous† |
295 |
--- |
-59 (-125, 7) |
132 |
|
|
||||
|
26 Week Serum COT |
||||
|
|
||||
|
Unexposed (< LOD) |
126 |
3282 |
Reference |
--- |
|
|
||||
|
SHS (LOD to 3 ng/mL) |
138 |
3302 |
20 (-135, 175) |
305 |
|
|
||||
|
Active (> 3 ng/mL) |
29 |
3144 |
-138 (-425, 150) |
554 |
|
|
||||
|
Continuous† |
293 |
--- |
-41 (-104, 21) |
125 |
|
|
||||
|
Birth Serum COT |
||||
|
|
||||
|
Unexposed (< LOD) |
121 |
3416 |
Reference |
--- |
|
|
||||
|
SHS (LOD to 3 ng/mL) |
131 |
3319 |
-97 (-248, 54) |
302 |
|
|
||||
|
Active (> 3 ng/mL) |
29 |
3226 |
-190 (-462, 82) |
545 |
|
|
||||
|
Continuous† |
281 |
--- |
-40 (-104, 24) |
128 |
|
|
||||
|
*-Adjusted for maternal age (18 to <25, 25 to <35, and 35+ years), race (non-Hispanic white, non-Hispanic black, and other), education (< 12, 12, and >12 years), martial status (married and unmarried), depression (minimal, mild, and moderate/severe), parity (0, 1, and >1) and maternal weight. †-Calculated by subtracting the lower 95% confidence limit from the upper 95% confidence limit ‡-Coefficients represent change in birth weight for a 10-fold increase in metabolite concentration. |
||||
|
Braun et al. Environmental Health 2010 9:53 doi:10.1186/1476-069X-9-53 |
||||
