Table 8 |
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Linear regression analysis of log(TSH) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994. |
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|
Independent variables |
All available subjects (n = 705) |
Susceptible subpopulations |
|
|
|
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|
HbA1c > 5.1% |
T4 ≤ 8.5 μg/dl |
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|
(n = 343) |
(n = 342) |
||
|
|
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|
Estimate (95% CI) |
Estimate (95% CI) |
Estimate (95% CI) |
|
|
|
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|
Intercept |
-0.487 |
0.134 |
-1.263 |
|
(-1.380, 0.407) |
(-1.235, 1.503) |
(-2.587, 0.061) |
|
|
|
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|
2,4-D, binary |
1.380 |
-0.915 |
2.537c |
|
(-0.395, 3.154) |
(-3.689, 1.858) |
(0.066, 5.007)c |
|
|
|
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|
Log(HDL) for 2,4-D < LOD |
0.209 |
0.125 |
0.309 |
|
(0.021, 0.397) |
(-0.172, 0.422) |
(0.032, 0.585)c |
|
|
|
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|
Log(HDL) for 2,4-D ≥ LOD |
-0.177 |
0.360 |
-0.371 |
|
(-0.620, 0.266) |
(-0.321, 1.042) |
(-0.981, 0.239) |
|
|
|
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|
Log(urinary creatinine) |
-0.010 |
-0.029 |
0.067 |
|
(-0.079, 0.059) |
(-0.135, 0.076) |
(-0.036, 0.170) |
|
|
|
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|
Gender |
0.024 |
0.052 |
0.004 |
|
(-0.075, 0.123) |
(-0.097, 0.202) |
(-0.147, 0.155) |
|
|
|
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|
Age (years) |
0.004 |
0.002 |
0.007 |
|
(-0.000, 0.009) |
(-0.005, 0.009) |
(0.000, 0.014)c |
|
|
|
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|
Non-Hispanic Black |
-0.264 |
-0.312 |
-0.346 |
|
(-0.377, -0.151)a |
(-0.486, -0.138)a |
(-0.512, -0.180)a |
|
|
|
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|
Mexican American |
-0.126 |
-0.227 |
-0.167 |
|
(-0.244, -0.007)c |
(-0.415, -0.040)c |
(-0.357, 0.023) |
|
|
|
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|
Other ethnicity |
-0.046 |
-0.072 |
-0.111 |
|
(-0.331, 0.238) |
(-0.477, 0.334) |
(-0.527, 0.306) |
|
|
|
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|
Past smoker |
-0.049 |
-0.192 |
-0.076 |
|
(-0.174, 0.076) |
(-0.374, -0.010)c |
(-0.256, 0.104) |
|
|
|
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|
Active smoker |
-0.117 |
-0.260 |
-0.080 |
|
(-0.220, -0.014)c |
(-0.416, -0.103)b |
(-0.235, 0.075) |
|
|
|
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|
BMI 25-29 kg/m2 |
0.100 |
0.106 |
0.215 |
|
(-0.005, 0.206) |
(-0.059, 0.271) |
(0.061, 0.369)b |
|
|
|
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|
BMI ≥ 30 kg/m2 |
0.148 |
0.156 |
0.304 |
|
(0.023, 0.274)c |
(-0.024, 0.336) |
(0.111, 0.498)b |
|
|
|
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|
Alcohol consumption |
-0.005 |
0.032 |
-0.003 |
|
(-0.167, 0.157) |
(-0.202, 0.263) |
(-0.212, 0.207) |
|
|
|
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|
Income ≥ 20K (%) |
-0.036 |
-0.053 |
0.015 |
|
(-0.132, 0.059) |
(-0.193, 0.087) |
(-0.130, 0.161) |
|
|
|
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|
Hours of fasting |
0.002 |
-0.001 |
-0.011 |
|
(-0.009, 0.012) |
(-0.016, 0.015) |
(-0.026, 0.005) |
|
|
|
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|
a p ≤ 0.001, b p ≤ 0.01, c p ≤ 0.05 P-values for the interaction term log(HDL)*2,4-D are 0.10 for all subjects, 0.52 for subjects with HbA1c > 5.1%, and 0.04 for subjects with T4 ≤ 8.5 μg/dl. |
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Schreinemachers Environmental Health 2010 9:11 doi:10.1186/1476-069X-9-11 |
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