Table 1 |
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|
Increase in dopamine level by TCDD exposure to N2a-Rβ cells |
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|
L-dopa and catecholamines |
Amount |
Fold increase |
|
|
|
|||
|
DMSO |
TCDD |
||
|
|
|||
|
L-dopa (ng/2 × 107cells) |
118.8 ± 18.9 |
208.8 ± 18.0 |
1.75** |
|
Dopamine (ng/2 × 107cells) |
17.7 ± 2.7 |
28.1 ± 2.9 |
1.59** |
|
Noradrenaline (pg/2 × 107cells) |
66.8 ± 11.1 |
71.5 ± 8.6 |
1.07 |
|
Adrenaline (pg/2 × 107cells) |
N.D. |
N.D. |
N.D. |
|
|
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|
L-dopa and catecholamines in N2a-Rβ cells were measured by a fluorescent HPLC method. Amounts of L-dopa and dopamine were significantly higher in TCDD-exposed N2a-Rβ cells as compared to unexposed N2a-Rβ cells. Fold increase represents the ratios of the amounts in TCDD-exposed cells to those in unexposed cells. No change was observed in the amount of noradrenaline with or without TCDD exposure to N2a-Rβ cells. Values are mean ± SD of four replicate determinations. ND, not detected. **P < 0.01. |
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Akahoshi et al. Environmental Health 2009 8:24 doi:10.1186/1476-069X-8-24 |
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