Table 6 |
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|
Associations between effect biomarkers and exposure information derived from questionnaires. |
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|
Effect biomarker |
n |
Parameter of exposure |
Confounding factors |
Regression coefficient |
Standerdized regression coefficient (95% CI) |
Squared semi-partial correlation |
p-value |
|
|
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|
PSA ng/mL (n = 770) |
770 |
Consumption of dairy fat |
A/S/LS/BMI |
0.009 |
0.071 (0.001, 0.142) |
0.005 |
0.047 |
|
CEA ng/mL (n = 829) |
829 |
Lifetime smoking |
A/S |
0.064 |
0.429 (0.313, 0.546) |
0.048 |
< 0.000001 |
|
Consumption of Alcohol |
A/S/LS |
0.030 |
0.174 (0.110, 0.237) |
0.027 |
< 0.000001 |
||
|
Exposure to solvents |
A/S/LS |
0.383 |
0.100 (0.038, 0.161) |
0.010 |
0.0015 |
||
|
Recent alcohol consumption |
A/S/LS |
0.046 |
0.096 (0.033, 0.160) |
0.008 |
0.0029 |
||
|
Consumption of fish fat |
A/S/LS |
0.070 |
0.069 (0.008, 0.131) |
0.005 |
0.027 |
||
|
Exposure to halogenated hydrocarbons |
A/S/LS |
0.266 |
0.068 (-0.080, 0.216) |
0.005 |
0.030 |
||
|
p53 pg/mL |
825 |
Consumption of fish fat |
A/S/LS |
9.836 |
0.097 (0.028, 0.166) |
0.009 |
0.0059 |
|
Consumption of fruit |
A/S/LS |
0.115 |
0.098 (0.029, 0.167) |
0.009 |
0.0056 |
||
|
Micronuclei (number per 1000 binucleated cells) |
773 |
Consumption of fish fat |
A/S/LS |
0.312 |
0.108 (0.043, 0.173) |
0.011 |
0.0011 |
|
Consumption of vegetables |
A/S/LS |
0.003 |
0.089 (0.024, 0.153) |
0.008 |
0.0072 |
||
|
DNA strand breaks (%DNA, comet assay) |
593 |
Consumption of meat fat |
A/S/RS |
-0.018 |
-0.125 (-0.208, -0.042) |
0.014 |
0.0033 |
|
Indoor stoking of diverse organic materials |
A/S/RS |
0.228 |
0.111 (0.030, 0.191) |
0.012 |
0.0072 |
||
|
Exposure to solvents |
A/S/RS |
0.208 |
0.102 (0.020, 0.184) |
0.010 |
0.015 |
||
|
Consumption of freshwater fish |
A/S/RS |
-0.447 |
-0.098 (-0.178, -0.018) |
0.010 |
0.017 |
||
|
Nuisance from noise (day) |
A/S/RS |
0.124 |
0.094 (0.014, 0.175) |
0.009 |
0.022 |
||
|
Nuisance from noise (night) |
A/S/RS |
0.170 |
0.087 (0.006, 0.167) |
0.007 |
0.036 |
||
|
Exposure to halogenated hydrocarbons |
A/S/RS |
0.179 |
0.086 (0.005, 0.167) |
0.007 |
0.039 |
||
|
|
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|
A multiple regression was performed with each effect biomarker as dependent variable with a measured exposure variable and confounding factors as independent variables. CI: confidence interval, n: number of cases, A = age, S = sex, LS = lifetime smoking, RS = recent smoking, BMI = body mass index. |
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|
De Coster et al. Environmental Health 2008 7:26 doi:10.1186/1476-069X-7-26 |
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