Table 2

Symptoms of the eyes and airways comparing different genotypes among TDI-exposed and non-exposed workers.a


Geno-type
 Symptoms





Yes (N)
 No (N)
 ORb
 95% CI
 Pc*
EYES
Exposed
 NAT1
 IM+S
 33
 53
 1.0
 -
 0.067


R
 23
 17
 2.2
 1.0–4.9
Unexposed
 NAT1
 IM+S
 19
 60
 1.0
 -


R
 6
 27
 0.63
 0.22–1.9
Exposed
 SULT1A1 R213H
 GG
 27
 14
 1.0
 -
 0.19


AG+AA
 29
 56
 0.22
 0.096–0.52
Unexposed
 SULT1A1 R213H
 GG
 13
 31
 1.0



AG+AA
 12
 56
 0.56
 0.22–1.4
Exposed
 TNF-308
 GG
 36
 44
 1.0
 -
 0.11


GA+AA
 17
 19
 1.0
 0.47–2.4
Unexposed
 TNF-308
 GG
 11
 57
 1.0
 -


GA+AA
 14
 25
 2.6
 1.0–7.0
WHEEZE
Exposed
 CYP1A1*2B
 I/I
 34
 87
 1.0
 -
 0.061


I/V
 5
 1
 14
 1.5–130
Unexposed
 CYP1A1*2B
 I/I
 23
 82
 1.0
 -


I/V
 1
 6
 0.83
 0.090–7.7
Exposed
 SULT1A1 R213H
 GG
 17
 25
 1.0
 -
 0.58


AG+AA
 22
 63
 0.52
 0.22–1.2
Unexposed
 SULT1A1 R213H
 GG
 14
 30
 1.0
 -


AG+AA
 10
 58
 0.38
 0.15–0.99
Exposed
 CCL5 -403
 GG
 19
 64
 1.0
 -
 0.42


AG+AA
 20
 21
 3.1
 1.3–7.1
Unexposed
 CCL5 -403
 GG
 13
 58
 1.0
 -


AG+AA
 10
 29
 1.8
 0.68–5.0
Exposed
 TNF-308
 GG
 29
 52
 1.0
 -
 0.043


GA+AA
 7
 30
 0.37
 0.14–0.99
Unexposed
 TNF-308
 GG
 13
 55
 1.0
 -


GA+AA
 10
 29
 1.3
 0.46–3.4
DRY COUGH
Exposed
 HLADQB1*05
 Absent
 20
 62
 1.0
 -
 0.047


Present
 18
 20
 2.7
 1.2–6.3
Unexposed
 HLADQB1*05
 Absent
 12
 74
 1.0
 -


Present
 1
 23
 0.27
 0.031–2.2
Exposed
 TNF-308
 GG
 30
 50
 1.0
 -
 0.023


GA+AA
 7
 28
 0.43
 0.17–1.1
Unexposed
 TNF-308
 GG
 6
 62
 1.0
 -


GA+AA
 7
 32
 2.2
 0.66–7.3
COUGH WITH MUCUS
Exposed
 GSTM1
 Present
 19
 45
 1.0
 -
 0.13


Absent
 24
 39
 1.4
 0.66–3.0
Unexposed
 GSTM1
 Present
 8
 55
 1.0
 -


Absent
 18
 31
 3.5
 1.3–9.4
Exposed
 GSTM3
 AA
 29
 61
 1.0
 -
 0.028


AB+BB
 14
 23
 1.2
 0.52–2.7
Unexposed
 GSTM3
 AA
 23
 53
 1.0
 -


AB+BB
 3
 33
 0.22
 0.059–0.81
Exposed
 GSTP1*105
 I/I
 26
 41
 1.0
 -
 0.019


I/V+V/V
 17
 43
 0.66
 0.32–1.4
Unexposed
 GSTP1*105
 I/I
 8
 48
 1.0
 -


I/V+V/V
 18
 38
 3.0
 1.1–8.0
Exposed
 CCL5 -403
 GG
 22
 59
 1.0
 -
 0.079


AG+AA
 21
 20
 2.9
 1.3–6.5
Unexposed
 CCL5 -403
 GG
 17
 54
 1.0
 -


AG+AA
 8
 31
 0.86
 0.32–2.3
NOSE BLEED
Exposed
 MPO
 GG
 25
 65
 1.0
 -
 0.018


AG+AA
 3
 30
 0.21
 0.056–0.94
Unexposed
 MPO
 GG
 3
 70
 1.0
 -


AG+AA
 4
 35
 2.9
 0.58–14

a Adjusted effect estimates (for sex, age, atopy, and smoking) are presented as odds ratios (OR) and 95% confidence intervals. Statistically significant results are presented in bold.

bAll results that reached statistical significance with respect to genotype-associated risk in either exposure-strata, or in the analysis of interaction between genotype and exposure status, are presented.

cAnalysis of interaction between exposure and genotype was performed in a separate model using logistic regression with interaction term. P-values regarding interaction between exposure and genotype are indicated by P*.

Broberg et al. Environmental Health 2008 7:15   doi:10.1186/1476-069X-7-15