Research
Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study
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* Corresponding author: James Dahlgren dahlgren@envirotoxicology.com
1 Department of Occupational and Environmental Medicine, UCLA School of Medicine, Los Angeles, CA, USA
2 James Dahlgren Medical, Santa Monica, CA, USA
3 Epidemiology Resources, Van Nuys, CA, USA
4 Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA
5 Stone Lions, Rolling Hills Estates, CA, USA
6 Comprehensive Health Screening Services, Santa Monica, CA, USA
Environmental Health 2007, 6:8 doi:10.1186/1476-069X-6-8
Published: 22 February 2007Abstract
Background
This is a community comparison study that examines persons living in a subdivision exposed to petroleum products and mercury.
Methods
We compared their health status and questionnaire responses to those living in another community with no known exposures of this type.
Results
Pristane house dust among the exposed homes was higher than in the comparison communities. The exposed subdivision has higher ambient air mercury levels compared to the control community. The prevalence of rheumatic diseases (OR = 10.78; CI = 4.14, 28.12) and lupus (OR = 19.33; CI = 1.96, 190.72) was greater in the exposed population compared to the unexposed. A higher prevalence of neurological symptoms, respiratory symptoms and several cardiovascular problems including stroke (OR = 15.41; CI = 0.78, 304.68) and angina (OR = 5.72; CI = 1.68, 19.43) was seen.
Conclusion
There were statistically significant differences in B cells, Natural Killer Cells, gamma glutamyl transferase, globulin and serum calcium levels between control and exposed subjects.