Table 4

Association of the CRS score (CRS ≤ 20; CRS > 20) with NAT2 genotype stratified by gender.
Gene
 Genotype
 CRS ≤ 20 n (%)
 CRS > 20 n (%)
 Univariate odds ratio (95% CIa)
 Multivariateb odds ratio (95% CI)
 Pc


Females (n = 298)
NAT2 fast
 *4/*4
 9 (6.8)
 7 (4.2)
 1.00d
 1.00d

*4/*5
 40 (30.1)
 30 (18.2)
 0.96 (0.32–2.88)
 0.97 (0.32–2.91)
 0.958

*4/*6
 24 (18.0)
 22 (13.3)
 1.18 (0.38–3.70)
 1.18 (0.37–3.70)
 0.780

*4/*7
 2 (1.5)
 3 (1.8)
 1.93 (0.25–14.89)
 2.01 (0.26–15.56)
 0.505
NAT2 slow
 *5/*5
 19 (14.3)
 35 (21.2)
 2.37 (0.76–7.37)
 2.38 (0.76–7.42)
 0.136

*5/*6
 29 (21.8)
 43 (26.1)
 1.91 (0.64–5.69)
 1.93 (0.64–5.77)
 0.241

*5/*7
 2 (1.5)
 3 (1.8)
 1.93 (0.25–14.88)
 1.92 (0.25–14.84)
 0.533

*6/*6
 8 (6.0)
 21 (12.7)
 3.38 (0.94–12.14)
 3.44 (0.95–12.44)
 0.059

*6/*7
 -
 1 (0.6)
 n.c.e
 n.c.e
 -

*7/*7
 -
 -
 -
 -
 -
NAT2 fast
 all
 75 (56.4)
 62 (37.6)
 1.00d
 1.00d
NAT2 slow
 all
 58 (43.6)
 103 (62.4)
 2.15 (1.35–3.42)
 2.16 (1.35–3.44)
 0.001


Males (n = 223)
NAT2 fast
 *4/*4
 6 (5.2)
 6 (5.6)
 1.00d
 1.00d

*4/*5
 28 (24.3)
 19 (17.6)
 0.68 (0.19–2.42)
 0.68 (0.19–2.52)
 0.568

*4/*6
 15 (13.0)
 12 (11.1)
 0.80 (0.20–3.13)
 0.73 (0.18–2.95)
 0.662

*4/*7
 1 (0.9)
 2 (1.9)
 2.00 (0.14–28.41)
 1.45 (0.10–21.03)
 0.786
NAT2 slow
 *5/*5
 30 (26.1)
 26 (24.1)
 0.87 (0.25–3.02)
 0.93 (0.26–3.34)
 0.905

*5/*6
 27 (23.5)
 31 (28.7)
 1.15 (0.33–3.98)
 1.18 (0.33–4.24)
 0.798

*5/*7
 2 (1.7)
 2 (1.9)
 1.00 (0.10–9.61)
 0.95 (0.09–9.65)
 0.963

*6/*6
 6 (5.2)
 10 (9.3)
 1.67 (0.37–7.61)
 1.61 (0.33–7.76)
 0.555

*6/*7
 -
 -
 -
 -
 -

*7/*7
 -
 -
 -
 -
 -
NAT2 fast
 all
 50 (43.5)
 39 (36.1)
 1.00d
 1.00d
NAT2 slow
 all
 65 (56.5)
 69 (63.9)
 1.36 (0.79–2.33)
 1.45 (0.82–2.56)
 0.199

Schnakenberg et al. Environmental Health 2007 6:6   doi:10.1186/1476-069X-6-6

Open Data