|
Association of the CRS score (CRS ≤ 20; CRS > 20) with NAT2 genotype stratified by gender. |
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| Gene |
Genotype |
CRS ≤ 20 n (%) |
CRS > 20 n (%) |
Univariate odds ratio (95% CIa) |
Multivariateb odds ratio (95% CI) |
Pc |
|
|
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| Females (n = 298) |
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|
|
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| NAT2 fast |
*4/*4 |
9 (6.8) |
7 (4.2) |
1.00d |
1.00d |
|
| *4/*5 |
40 (30.1) |
30 (18.2) |
0.96 (0.32–2.88) |
0.97 (0.32–2.91) |
0.958 |
|
| *4/*6 |
24 (18.0) |
22 (13.3) |
1.18 (0.38–3.70) |
1.18 (0.37–3.70) |
0.780 |
|
| *4/*7 |
2 (1.5) |
3 (1.8) |
1.93 (0.25–14.89) |
2.01 (0.26–15.56) |
0.505 |
|
|
|
||||||
| NAT2 slow |
*5/*5 |
19 (14.3) |
35 (21.2) |
2.37 (0.76–7.37) |
2.38 (0.76–7.42) |
0.136 |
| *5/*6 |
29 (21.8) |
43 (26.1) |
1.91 (0.64–5.69) |
1.93 (0.64–5.77) |
0.241 |
|
| *5/*7 |
2 (1.5) |
3 (1.8) |
1.93 (0.25–14.88) |
1.92 (0.25–14.84) |
0.533 |
|
| *6/*6 |
8 (6.0) |
21 (12.7) |
3.38 (0.94–12.14) |
3.44 (0.95–12.44) |
0.059 |
|
| *6/*7 |
- |
1 (0.6) |
n.c.e |
n.c.e |
- |
|
| *7/*7 |
- |
- |
- |
- |
- |
|
| NAT2 fast |
all |
75 (56.4) |
62 (37.6) |
1.00d |
1.00d |
|
| NAT2 slow |
all |
58 (43.6) |
103 (62.4) |
2.15 (1.35–3.42) |
2.16 (1.35–3.44) |
0.001 |
|
|
||||||
| Males (n = 223) |
||||||
|
|
||||||
| NAT2 fast |
*4/*4 |
6 (5.2) |
6 (5.6) |
1.00d |
1.00d |
|
| *4/*5 |
28 (24.3) |
19 (17.6) |
0.68 (0.19–2.42) |
0.68 (0.19–2.52) |
0.568 |
|
| *4/*6 |
15 (13.0) |
12 (11.1) |
0.80 (0.20–3.13) |
0.73 (0.18–2.95) |
0.662 |
|
| *4/*7 |
1 (0.9) |
2 (1.9) |
2.00 (0.14–28.41) |
1.45 (0.10–21.03) |
0.786 |
|
|
|
||||||
| NAT2 slow |
*5/*5 |
30 (26.1) |
26 (24.1) |
0.87 (0.25–3.02) |
0.93 (0.26–3.34) |
0.905 |
| *5/*6 |
27 (23.5) |
31 (28.7) |
1.15 (0.33–3.98) |
1.18 (0.33–4.24) |
0.798 |
|
| *5/*7 |
2 (1.7) |
2 (1.9) |
1.00 (0.10–9.61) |
0.95 (0.09–9.65) |
0.963 |
|
| *6/*6 |
6 (5.2) |
10 (9.3) |
1.67 (0.37–7.61) |
1.61 (0.33–7.76) |
0.555 |
|
| *6/*7 |
- |
- |
- |
- |
- |
|
| *7/*7 |
- |
- |
- |
- |
- |
|
| NAT2 fast |
all |
50 (43.5) |
39 (36.1) |
1.00d |
1.00d |
|
| NAT2 slow |
all |
65 (56.5) |
69 (63.9) |
1.36 (0.79–2.33) |
1.45 (0.82–2.56) |
0.199 |
Schnakenberg et al. Environmental Health 2007 6:6 doi:10.1186/1476-069X-6-6 |
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