|
Association of the CRS score (CRS ≤ 20; CRS > 20) with NAT2, GSTM1, GSTP1 and GSTT1. |
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| Gene |
Genotype |
CRS ≤ 20 n (%) |
CRS > 20 n (%) |
Univariate odds ratio (95% CIa) |
Multivariateb odds ratio (95% CI) |
Pc |
|
|
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| n = 248 |
n = 273 |
|||||
|
|
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| NAT2 fast |
*4/*4 |
15 (6.0) |
13 (4.8) |
1.00d |
1.00d |
|
| *4/*5 |
68 (27.4) |
49 (17.9) |
0.83 (0.36–1.90) |
0.83 (0.36–1.92) |
0.668 |
|
| *4/*6 |
39 (15.7) |
34 (12.5) |
1.01 (0.42–2.41) |
0.97 (0.40–2.33) |
0.937 |
|
| *4/*7 |
3 (1.2) |
5 (1.8) |
1.92 (0.38–9.65) |
1.88 (0.37–9.47) |
0.446 |
|
|
|
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| NAT2 slow |
*5/*5 |
49 (19.8) |
61 (22.3) |
1.44 (0.62–3.30) |
1.51 (0.65–3.50) |
0.339 |
| *5/*6 |
56 (22.6) |
74 (27.1) |
1.52 (0.67–3.46) |
1.57 (0.69–3.60) |
0.286 |
|
| *5/*7 |
4 (1.6) |
5 (1.8) |
1.44 (0.32–6.53) |
1.46 (0.32–6.71) |
0.627 |
|
| *6/*6 |
14 (5.6) |
31 (11.4) |
2.55 (0.96–6.77) |
2.56 (0.95–6.89) |
0.062 |
|
| *6/*7 |
- |
1 (0.4) |
n.c.e |
n.c.e |
- |
|
| *7/*7 |
- |
- |
- |
- |
- |
|
|
|
||||||
| NAT2 fast |
all |
125 (50.4) |
101 (37.0) |
1.00d |
1.00d |
|
| NAT2 slow |
all |
123 (49.6) |
172 (63.0) |
1.73 (1.22–2.46) |
1.81 (1.27–2.59) |
0.001 |
| GSTM1 |
*1/*1 or *0/*1 |
143 (57.7) |
109 (39.9) |
1.00d |
1.00d |
|
| *0/*0 |
105 (42.3) |
164 (60.1) |
2.05 (1.44–2.91) |
2.08 (1.46–2.96) |
0.0001 |
|
| GSTT1 |
*1/*1 or *0/*1 |
226 (91.1) |
214 (78.4) |
1.00d |
1.00d |
|
| *0/*0 |
22 (8.9) |
59 (21.6) |
2.83 (1.68–4.78) |
2.80 (1.65–4.75) |
0.0001 |
|
| GSTP1 |
*A/*A |
106 (42.7) |
117 (42.9) |
1.00d |
1.00d |
|
| *A/*B |
82 (33.1) |
101 (37.0) |
1.12 (0.75–1.65)e |
1.17 (0.79–1.75)e |
0.433 |
|
| *A/*C or *B/*D |
29 (11.7) |
20 (7.3) |
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| *A/*D |
2 (0.8) |
5 (1.8) |
||||
| *B/*B |
21 (8.5) |
22 (8.1) |
||||
| *B/*C |
5 (2.0) |
7 (2.6) |
||||
| *C/*C |
3 (1.2) |
1 (0.4) |
||||
| *C/*D |
- |
- |
||||
| *D/*D |
- |
- |
||||
| all except *A/*A |
142 (57.3) |
156 (57.1) |
1.00 (0.70–1.41) |
1.04 (0.73–1.48) |
0.83 |
|
|
aconfidence interval; badjusted for age (continous); gender; smoking (current; former; never); cmultivariate logistic regression; dreference category; ecomprising all variant GSTP1 genotypes. | ||||||
Schnakenberg et al. Environmental Health 2007 6:6 doi:10.1186/1476-069X-6-6 |
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