Table 4 |
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|
The effect of quartiles of arsenic on logged urinary 8-OHdG (μg/l) by GSTM1 genotype (N = 290) |
||||||
| GSTM1 positive |
GSTM1 null |
Wald p-value† |
LRT p-value†† |
|||
|
|
||||||
| Model* |
β |
95% CI |
β |
95% CI |
||
|
|
||||||
| Total urinary arsenic quartile (μg/l) |
0.007 |
|||||
| 1.35 – 13.3 |
reference |
reference |
||||
| >13.3 – 22.6 |
-0.12 |
(-0.46, 0.22) |
0.84 |
(0.27, 1.42) |
0.004 |
|
| >22.6 – 47.9 |
-0.06 |
(-0.43, 0.31) |
0.98 |
(0.33, 1.66) |
0.005 |
|
| >47.9 – 431.3 |
-0.15 |
(-0.60, 0.30) |
0.85 |
(0.27, 1.44) |
0.004 |
|
| Drinking water arsenic quartile (μg/l) |
0.69 |
|||||
| 0.5 |
reference |
reference |
||||
| >0.50 – 1.5 |
-0.05 |
(-0.42, 0.31) |
0.26 |
(-0.41, 0.93) |
0.43 |
|
| >1.5 – 81.7 |
0.29 |
(-0.11, 0.69) |
0.15 |
(-0.46, 0.75) |
0.69 |
|
| >81.7 – 591 |
-0.21 |
(-0.66, 0.24) |
0.002 |
(-0.74, 0.75) |
0.63 |
|
| Toenail arsenic quartile (μg/g) |
0.69 |
|||||
| 0.2 – 0.6 |
reference |
reference |
||||
| >0.6 – 0.8 |
-0.19 |
(-0.71, 0.33) |
-0.09 |
(-0.93, 0.75) |
0.83 |
|
| >0.8 – 1.6 |
-0.36 |
(-0.87, 0.14) |
-0.22 |
(-1.06, 0.63) |
0.77 |
|
| >1.6 – 10.2 |
-0.49 |
(-1.00, 0.03) |
0.05 |
(-0.76, 0.87) |
0.26 |
|
|
|
||||||
|
*Main effects are from three random effects Tobit models adjusted for logged creatinine, BMI, age, betelnut chewing, environmental tobacco smoke, and education (secondary or higher vs primary or less), and hOGG1 and APE1 genotypes. † significance test for individual interaction terms. †† significance test for the entire group of arsenic quartile by gene interactions |
||||||
|
Breton et al. Environmental Health 2007 6:39 doi:10.1186/1476-069X-6-39 |
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