|
Prevalence (% [n]) of liver and kidney histopathology in East Greenland polar bears sampled during 1999–2002 |
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| Organ |
Absent |
Mild |
Moderate |
Severe |
Age p (F) |
|
|
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| Liver (n = 59) |
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| Multifocally mononuclear cell infiltrations |
89 (53) |
11 (6) |
- |
- |
n.s. |
| Portal mononuclear cell infiltrations |
85 (50) |
8 (5) |
7 (4) |
- |
n.s. |
| Lipid granulomas |
37 (22) |
36 (21) |
22 (13) |
5 (3) |
n.s. |
| Hepatocytic steatosis |
- |
24 (14) |
24 (14) |
52 (31) |
n.s. |
| Ito cell lipid accumulation |
36 (21) |
14 (8) |
19 (11) |
31 (19) |
** (7.8) |
| Bile duct proliferation with fibrosis |
92 (54) |
8 (5) |
- |
- |
*** (15.6) |
| Kidney (n = 57) |
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| Glomerular diffuse capillary wall thickening |
72 (41) |
25 (14) |
3 (2) |
- |
*** (8) |
| Glomerular mesangial deposits/sclerosis |
22 (13) |
39 (22) |
39 (22) |
- |
* (5.6) |
| Interstitial fibrosis |
75 (42) |
12 (7) |
13 (8) |
- |
*** (49.8) |
| Tubular epithelial cell hyperplasia |
75 (42) |
12 (7) |
13 (8) |
- |
** (6.7) |
| Tubular hyalinization/atrophy/dilatation/necrosis |
61 (35) |
12 (7) |
27 (15) |
- |
*** (30.8) |
| Tubular medullar hyaline casts |
84 (48) |
13 (8) |
3 (1) |
- |
* (6.6) |
| Mononuclear cell infiltrations |
39 (22) |
42 (24) |
19 (11) |
- |
n.s. |
|
Lesions are divided into groups of absent, mild, moderate and severe. n.s.: individuals with lesions not significantly older (mean age) than individuals without lesions at p > 0.05. *: individuals with lesions significantly older (mean age) than individuals without lesions at p ≤ 0.05, **: at p ≤ 0.01 and ***: at p ≤ 0.001. | |||||
Sonne et al. Environmental Health 2007 6:11 doi:10.1186/1476-069X-6-11 |
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