|
Genes altered following oxythioquinox exposure. Table represents data mined from HuGeneFL microarrays (Affymetrix). All genes selected have a signal log ratio of ± 0.6 unless otherwise noted. Representative genes for each group were selected based on their function and are shown here. |
|||
| GenBank ID |
Name |
Peak Expression Level (SLR) |
Functional Class |
|
|
|||
| Genes increased in three or more strains (n = 13): |
|||
| U22028 |
CYP2A13 |
1.5 |
xenobiotic metabolism |
| U20734 |
junB |
3.42 |
transcription |
| V01512 |
cfos |
2.04 |
transcription |
| S85655 |
prohibitin |
0.75 |
cell proliferation |
| S82240 |
RhoE GTPase |
2.81 |
signal transduction |
| M69043 |
MAD-3 mRNA encoding IkB-like activity |
0.83 |
apoptosis |
| M63573 |
cyclophilin |
1.68 |
immune response |
| U05861 |
Dihydrodiol dehydrogenase |
2.52 |
xenobiotic metabolism |
| Genes decreased in three or more strains (n = 23): |
|||
| L05624 |
MAP Kinase Kinase |
-0.67 |
signal transduction |
| U18018 |
E1A enhancer |
-1.34 |
transcription |
| X56681 |
junD |
-1.03 |
transcription |
| X68836 |
S-adenosylmethionine synthetase |
-2.57 |
cell metabolism |
| J04973 |
Cytochrome bc-1 |
-3.12 |
cell metabolism |
| Genes altered in at least two of four cell strains (n = 189): |
|||
| X03484 |
raf oncogene |
1.46 |
carcinogenesis |
| M60974 |
growth arrest and DNA-damage-inducible protein (gadd45) |
1.51 |
DNA damage |
| M57731 |
Human gro-beta |
1.85 |
immune response |
| X66899 |
EWS |
1.2 |
carcinogenesis |
| Z29087* |
Cyclin D1 Promoter |
1.03 |
cell cycle control |
| L10910 |
Splicing Factor CC1.3 |
0.62 |
RNA processing |
| M83667 |
NF-IL6 Permeability Factor |
1.55 |
transcription |
| M27281 |
Vascular Permeability Factor |
-1.09 |
cell proliferation |
| L28010 |
HnRNP F protein |
-0.55 |
RNA processing |
| U72649 |
BTF2 |
-1.86 |
carcinogenesis |
| M19267 |
tropomyosin |
-1.16 |
cardiac |
| M38258 |
retinoic acid receptor gamma 1 |
-0.94 |
cell metabolism |
| U42031 |
Immunophilin |
-1.41 |
immune response |
| U67122 |
ubiquitin-related SUMO-1 |
-1.03 |
protein metabolism |
| X70340 |
Transforming growth factor alpha |
-0.57 |
cell proliferation |
| M34458 |
Lamin B |
-1.33 |
cell proliferation |
|
*No accession number was used by Affymetrix. This accession number most closely matches the probe description and sequence. | |||
Gwinn et al. Environmental Health: A Global Access Science Source 2004 3:9 doi:10.1186/1476-069X-3-9 |
|||