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A national case-crossover analysis of the short-term effect of PM2.5 on hospitalizations and mortality in subjects with diabetes and neurological disorders

Environmental Health volume 13, Article number: 38 (2014) Cite this article

Abstract

Background

Diabetes and neurological disorders are a growing burden among the elderly, and may also make them more susceptible to particulate air matter with aerodynamic diameter less than 2.5 μg (PM2.5). The same biological responses thought to effect cardiovascular disease through air pollution-mediated systemic oxidative stress, inflammation and cerebrovascular dysfunction could also be relevant for diabetes and neurodegenerative diseases.

Methods

We conducted multi-site case-crossover analyses of all-cause deaths and of hospitalizations for diabetes or neurological disorders among Medicare enrollees (>65 years) during the period 1999 to 2010 in 121 US communities. We examined whether 1) short-term exposure to PM2.5 increases the risk of hospitalization for diabetes or neurological disorders, and 2) the association between short-term exposure to PM2.5 and all-cause mortality is modified by having a previous hospitalization of diabetes or neurological disorders.

Results

We found that short term exposure to PM2.5 is significantly associated with an increase in hospitalization risks for diabetes (1.14% increase, 95% CI: 0.56, 1.73 for a 10 μg/m3 increase in the 2 days average), and for Parkinson’s disease (3.23%, 1.08, 5.43); we also found an increase in all-cause mortality risks (0.64%, 95% CI: 0.42, 0.85), but we didn’t find that hospitalization for diabetes and neurodegenerative diseases modifies the association between short term exposure to PM2.5 and all-cause mortality.

Conclusion

We found that short-term exposure to fine particles increased the risk of hospitalizations for Parkinson’s disease and diabetes, and of all-cause mortality. While the association between short term exposure to PM2.5 and mortality was higher among Medicare enrollees that had a previous admission for diabetes and neurological disorders than among Medicare enrollees that did not had a prior admission for these diseases, the effect modification was not statistically significant. We believe that these results provide useful insights regarding the mechanisms by which particles may affect the brain. A better understanding of the mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system.

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Background

There is clear evidence that long- and short-term exposures to particulate air pollution are associated with both acute and chronic mortality risk; multi-site studies have shown that ambient particulate pollution is associated with increased risk of deaths or hospitalizations for broadly defined cardiovascular disease [1–9]. Several studies have also reported associations between short-term particulate matter (PM2.5) exposure and cerebrovascular disease and stroke [10–15]. Two studies examined the association between pollution and mortality [16] or admission [12] separately by stroke type and found that pollution was associated with ischemic but not hemorrhagic stroke.

The mechanisms responsible for the effects of pollution on cerebrovascular disease and stroke are not fully understood, but could be mediated through a combination of autonomic, hemostatic, inflammatory, and vascular endothelial disturbances with consequent changes in cardiac and vascular function. For example some studies have suggested that particulate air matter with aerodynamic diameter less than 2.5 μg (PM2.5) may be associated with increased blood pressure, increased peripheral vascular resistance, decreased brachial artery diameter, and decreased brachial artery flow–mediated dilation [17–23]. Other studies found that PM2.5 may be associated with increased C-reactive protein [24, 25]. PM2.5 and its components have also been shown to increase oxidative stress, [24, 26–28] to decrease plaque stability [29, 30], and to increase atherosclerosis [31]. Derangements in cerebral vascular function have been associated with stroke incidence, as well as cognitive impairment, dementia, and depression. Vascular oxidative stress and inflammation are key pathogenic factors in neurovascular dysfunction [32]. The endothelial dysfunction induced by oxidative stress can release vascular endothelial growth factor and prostanoids, which promote vascular leakage, protein extravasation, and cytokine production [32].

Given the documented associations between exposure to ambient particulate air pollution and cerebrovascular events, peripheral vascular function, cerebral vascular function [33, 34], but also oxidative stress and inflammation, we can hypothesize that PM2.5 may also affect neurological disorders such as dementia, Alzheimer’s and Parkinson’s. Air pollution exposure has been hypothesized to increased inflammation in the brain [35], and brain inflammation has been implicated in the development of Alzheimer’s disease (AD) [36]. Therefore the same biological responses thought to effect cardiovascular disease through air pollution-mediated systemic oxidative stress and inflammation could also be relevant for diabetes and neurodegenerative diseases [15, 37].

Two recent studies have reported associations of traffic with lower cognitive function in elderly men [38] and with older women in the Nurses’ Health Study [39]. Several epidemiological studies have shown that people with diabetes are vulnerable to cardiovascular health effects associated with exposure to particle air pollution [20, 40–43]. People with diabetes are at greater risk for acute environmental perturbations of vascular function because of chronic endothelial dysfunction, autonomic dysregulation, atherosclerosis, or dysregulation of fluid balance and the renin-angiotensin system [44, 45]. Hence neurological disorders and diabetes are plausible targets for PM2.5.

The elderly represent a particularly susceptible population, and the growth in the number and proportion of older adults in the United States is unprecedented. Diabetes, cognitive decline, Parkinson’s disease, dementia, and Alzheimer's disease are also a growing burden. Alzheimer’s disease is the most common cause of dementia among older people. Estimates vary, but experts suggest that as many as 5.1 million Americans may have AD, while in 2006 there were 26.6 million cases worldwide. Dementia is the loss of cognitive functioning and memory, vascular dementia is due to many small strokes. Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory, thinking, and behavior. Parkinson's disease is a disorder of the brain that leads to shaking (tremors) and difficulty with walking, movement, and coordination; it can occur when the nerve cells in the brain that make dopamine are slowly destroyed, resulting in impairment of muscular control by that neurotransmitter. Parkinson's disease has also been related to autonomic dysfunction. Multiple sclerosis (MS) is an autoimmune disease that affects the brain and spinal cord, and it is caused by nerve damage which in turn can be caused by inflammation. For at least 20 years, diabetes rates in North America have been increasing substantially. The increasing prevalence of diabetes makes this susceptibility factor especially important to study.

The hypotheses of this study are: 1) short term exposure to PM2.5 might be associated with an increased risk of hospitalizations for diabetes or neurological disorders in the elderly; and 2) elderly with diabetes or neurological disorders may have higher risk of deaths from short term exposure to PM2.5 compared to elderly without these conditions. Thus, the purpose of this investigation is twofold: we will estimate the effect of short-term exposure of PM2.5 on 1) hospitalizations for neurological disorders and diabetes, and 2) on all-cause mortality in all Medicare deaths. Importantly we will also assess whether the mortality risks associated with PM2.5 among the elderly are modified by a previous hospital admission for a neurological disorder or diabetes.

To achieve these aims we will conduct a multi-site case-crossover study, where for each county, we estimate: 1) the short-term effects of PM2.5 on hospitalizations for neurological disorders and diabetes; 2) the short-term effects of PM2.5 on all-cause mortality; 3) and the short-term effects of PM2.5 on all-cause mortality in a susceptible population defined as persons 65 or older with at least one Medicare covered hospital admission for diabetes or neurological disorders.

Methods

Health data

We used the Medicare beneficiary denominator file from the Centers for Medicare and Medicaid services (CMS) to identify beneficiaries who were enrolled in the Medicare fee-for-service (FFS) plan between 1999 and 2010. The denominator file contains information on beneficiaries’ eligibility and enrollment in Medicare and the date of death was cross-referenced with the Social Security Administration's Master Beneficiary Record [46].

From the initial denominator file we excluded beneficiaries with age < 65 years, those enrolled in managed-care programs over an entire year, and those who resided outside of the targeted counties. We identified all deaths by selecting those subjects who died among all Medicare enrollees denominator file.

We linked the person-years beneficiary data with the Medicare Provider Analysis and Review (MEDPAR) inpatient data to identify all Medicare FFS patients who were hospitalized for the targeted medical conditions. The MEDPAR inpatient data includes information on patient demographics (age, sex, race), dates of admission and discharge, admission sources and types, principal and secondary diagnosis codes, and procedure codes, defined by the International Classification of Diseases, Ninth Revision, (ICD-9).

We used the Medicare claims records from the Medicare Provider Analysis and Review (MEDPAR) file to select only emergency admissions, and to identify previous cause of hospital admissions, based on primary and secondary diagnosis codes of all hospitalizations for any causes up to one year prior to the initial condition-specific hospitalization. Because diabetes and neurological disorders might not be the primary reason for an admission, individuals for whom the condition was noted as the primary admission cause or as any of nine coexisting conditions were classified as having the condition for the mortality analysis. We excluded patients who could not be merged with the Medicare denominator file.

The medical conditions that we examined were: diabetes (ICD-9: 250), dementia (ICD-9: 290), Alzheimer's disease (ICD-9: 331.0), Parkinson's disease (ICD-9: 332), and multiple sclerosis (ICD-9: 340). The primary code of admission reflects the main cause of admissions and therefore we used only primary emergency admissions to study the effect of PM2.5 on hospitalization.

The research was approved by the institutional review boards (IRB) of the Harvard School of Public Health.

Environmental data

We obtained particulate air matter with aerodynamic diameter less than 2.5 μg (PM2.5) data from US Environmental Protection Agency’s Air Quality System Technology Transfer Network (U.S. EPA Technology Transfer Network, 2005) which provide daily PM2.5 concentrations from the U.S. EPA’s National and State Local Ambient Monitoring stations (NAMS and SLAMS).

For most cities, the metropolitan county encompassed the city and much of its suburbs; therefore we aggregated counties where the city’s population extends beyond the boundaries of one county; henceforth we refer to the analyzed geographical areas as “community”.

Given that PM2.5 is not available daily in every city, to be included in our study, we required that at least 219 (60% of days) days of data in at least one year be available in each community. With this criterion, we selected 121 communities (180 counties) across the US for the years 1999–2010, based on the availability of air pollution, and representing a geographic distribution across the country.

Many of the communities have more than one monitoring location, requiring a method to average over multiple locations. Therefore we computed the community daily mean PM2.5 concentrations using an algorithm previously described [47, 48] that accounts for the different monitor-specific means and variances.

We defined our exposure as the 2 days average of PM2.5, that is, the average of the same (lag 0) and previous (lag 1) day. We present the results as percent change in mortality (or cause specific hospital admission) for 10 μg/m3 increase in the two days average of PM2.5.

We obtained local meteorological data from the National Oceanic and Atmospheric Administration (NOAA), including daily temperature (mean, min, max), daily dew point, date, and weather station.

Analytical strategy

To estimate the short-term effects of PM2.5 on hospitalizations for neurological disorders and diabetes, and to determine whether the mortality risks associated with short-term PM2.5 among elderly is exacerbated by a previous hospital admission for neurological disorders or diabetes, we conducted a community specific case-crossover analysis.

We created indicator variables denoting whether or not an individual had a primary or secondary hospitalization for diabetes or neurological disorder at any time before death. In the model having as outcome all-cause deaths, we also examined effect modification by specific cause of prior admission by including an interaction terms between PM2.5 and these indicator variables in the same model.

The case-crossover design was developed as a variant of the case–control design to study the effects of transient exposures on acute events [49]. This design samples only cases and compares each subject’s exposure experience in a time period just prior to a case-defining event with that subject’s exposure at other times. Since there is perfect matching on all measured or unmeasured subject characteristics that do not vary over time there can be no confounding by those characteristics.

Bateson and Schwartz [50, 51] demonstrated that by choosing control days close to event days, even very strong confounding of exposure by seasonal patterns could be controlled by design in the case control approach. This makes the approach an attractive alternative to the Poisson models for time series analysis.

We applied the time-stratified case-crossover design, and we defined the case as the day of death (or hospitalization); we then chose control days as every third day in the same month and year as the case.

The analysis was conducted for the hospitalization data and for the mortality data for each community separately, and we applied a conditional logistic regression controlling for day of the week and weather. To control for the potential confounding by weather, we included into the regression model average temperature for the same and previous day. Since risk may vary nonlinearly with temperature, we used a regression spline (with 3 degrees of freedom) both for the same and previous day. The effect of PM2.5 on hospitalization and mortality was modeled linearly.

Case-crossover analyses lend themselves to the analysis of effect modification. To determine whether the mortality risks associated with short-term PM2.5 among elderly is modified by a previous hospital admission of neurological disorders or diabetes, we included into the same regression model interaction terms between PM2.5 and the indicator variables indicating whether or not an individual had a primary or secondary hospitalization for diabetes, Parkinson’s disease, Alzheimer’s disease, and dementia.

To examine effect modification by sex, age (65–75, >75) or race (black, white, other races) we ran the conditional logistic regression stratified by each demographic characteristic. To compare the differences between the risk estimates in two categories of a potential effect modifier (e.g., the difference between males and females) we computed the 95 percent confidence interval as: Q ^ 1 - Q ^ 2 ± 1.96 SE ^ 1 2 + SE ^ 2 2 where and Q ^ 1 and Q ^ 2 are the estimates for the two categories (e.g., males and females), and S E 1 ^ and S E 2 ^ are their respective standard errors. We reject the null hypothesis that the group means are the same if the interval does not contain zero [52].

In a second stage of the analysis, the community specific results of the first stage analyses were combined using the multivariate meta-analysis technique of Berkey and coworkers [53]. To be conservative we report the results incorporating a random effect, whether or not there was a significant heterogeneity.

Results

From the Medicare beneficiary denominator file we selected 6,982,678 deaths among all Medicare enrollees during the period 1999 to 2010 in 121 US communities. From the Medicare data we selected the subjects 65 and older who were hospitalized for the targeted medical conditions.

Table 1 shows the descriptive statistics for the counts of deaths, counts of previous cause-specific hospitalization among those who died; and the number of cause-specific hospital admissions summarized across the 121 communities. Among the subjects who died during the study period (approximately 7 million) in all the communities, 13.7%, 3.8%, and 3.3% of subjects had a previous hospitalization noting as a cause or a comorbid condition diabetes, Alzheimer’s disease, and dementia respectively. Parkinson's disease and multiple sclerosis represent a lower proportion of persons with this specific admission. The primary emergency cause-specific hospitalizations in the same table follow the same pattern, with the higher number of hospitalizations for diabetes, and Alzheimer’s disease, and very few primary admissions for multiple sclerosis.

Table 1 Counts of deaths among Medicare enrollees; counts of cause-specific admission prior to death; and counts of cause-specific primary emergency hospitalizations, summarized over the 121 cities
Full size table

Figure 1 shows the location of the 121 US communities included in the study; the symbol size represent the population in each community, while the color represent the average PM2.5 concentrations during the entire study period. High levels of PM2.5 (red) are in California and in the industrial Midwest.

Figure 1
figure 1

Map of the US with the location of the 121 communities; the symbol size represent the population in each community, while the color represent the average PM 2.5 in the community.

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Additional file 1: Table S1 presents for each of the 121 communities the daily mean concentration levels for PM2.5, and of temperature; the total number of deaths and total number of previous admissions before death for dementia, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and diabetes. Additional file 1: Table S2 shows the counts of primary emergency cause-specific hospitalizations. Due to the small number of primary admission for multiple sclerosis we excluded these from the hospitalization analysis.

Table 2 presents the results of the analyses for 1) all-cause mortality and 2) primary cause-specific hospital admissions. We found a 0.64% increase (95% CI: 0.42, 0.85) in all-cause mortality for each 10 μg/m3 increase in the two days average of PM2.5 among all Medicare participants. We also found 0.60% increase (95% CI: 0.36, 0.84) in all-cause mortality among persons who had never been hospitalized for the specified conditions during the study period. We also found a significant, and larger, association between short-term exposure to PM2.5 and all-cause mortality in subjects with previous hospital admissions for diabetes (0.76%; 0.39, 1.12), Parkinson’s disease (1.15%; 0.09, 2.23), dementia (0.94%; 0.01, 1.89), Alzheimer’s disease (1.04%; 0.36, 1.72). However these differences were not statistically significant.

Table 2 Percent increase for 10 μg/m 3 increase in the two days average PM 2.5 : Combined across the 121 communities
Full size table

Table 2 summarizes also the results for cause-specific hospital admissions. For each 10 μg/m3 increase in the two days average of PM2.5 we found statistically significant increases in hospital admissions for Parkinson’s disease (3.23%; 95% CI: 1.08, 5.43), and diabetes (1.14%; 95% CI: 0.56, 1.73). The results for the other admissions causes are positive but non-significant due to the small number of cases in some cities, hence large confidence intervals in the meta-analysis.When the analysis was stratified by sex, race and age group we did not find significant evidence of effect modification by any of the demographic characteristics in the mortality analysis (Figure 2). In the hospital admissions analysis (Figure 3) instead we found that age was a significant modifier (P-value = 0.009) in Alzheimer’s disease with a 3.48% (95% CI: 0.83, 6.19) increase in subjects with an age between 65 and 75 years compared to a -0.27% (95% CI: -1.59, 1.06) increase in hospitalizations in subjects with over 75 years of age. The results by race are very unstable due to the distribution by race and cause of admissions.

Figure 2
figure 2

Percent increase in total mortality for 10 μg/m 3 increase in the two days average PM 2.5 for all Medicare deaths and separately by specific previous cause of admission and by demographics characteristics. The results are combined across the 121 communities.

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Figure 3
figure 3

Percent increase in cause specific primary emergency hospital admissions for 10 μg/m 3 increase in the two days average PM 2.5 separately by specific cause of admission and by demographics characteristics. The results are combined across the 121 communities.

Full size image

Because of our novel association between PM2.5 and admissions for neurological disorders, we also examined the effect of up to 3 previous days (lags 0, 1, 2) and the cumulative effect expressed by the moving average of PM2.5 up to 6 previous days (moving average from 2 days (01) up to 6 days (05)) (Figure 4). We found that the effects are immediate at lag 0 and persist for 2 or 3 days averages of PM2.5.

Figure 4
figure 4

Percent increase in cause specific primary emergency hospital admissions for 10 μg/m 3 increase in PM 2.5 for lags 0, 1, 2 and moving average from 2 days (01) up to 6 days (05). The results are combined across the 121 communities.

Full size image

Discussion

Most early attention to the association of particles with hospitalization and mortality has focused on heart and lung disease; lately interest has shifted to cerebrovascular disease, stroke, and cognitive impairment. In this multi-city study we found that short term exposure to fine particles increase the risk of all-cause mortality and of hospitalizations for diabetes and neurological disorders.

This is the first study to examine susceptible population defined as those elderly with a hospitalization for dementia, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.

We found significant effects of PM2.5 on hospitalization for Parkinson’s disease and diabetes; and in subjects aged 65–75 with Alzheimer’s disease. We also found that short term exposure to fine particles increased mortality risk in subjects with previous admissions for diabetes, Parkinson’s disease, dementia, and Alzheimer’s disease. While those risks were not significantly higher than the mortality risk associated with short-term effect of PM2.5 among then Medicare enrollees that were never hospitalized for any of these diseases, there was a pattern of higher estimates. The lack of significant effect modification of the mortality risk by pre-existing neurological disease could be due to limitation in the data used. More specifically, Medicare data only report hospitalization by cause and therefore we are not capturing enrollees with dementia or neurological disorder who are not hospitalized.

While this study focus on the mortality and hospitalizations of adults over the age of 65 with a specific admission for neurological disorder, previous studies have reported direct effects of particles on neurological outcomes including cognitive function. This suggests common pathways, which may explain the associations we saw.

In Germany elderly women were tested for mild cognitive impairment and the authors found that chronic exposure to traffic-related PM2.5 may be involved in the pathogenesis of Alzheimer’s disease [54]. Power and co-authors found that exposure to black carbon, a marker of traffic-related particles, was associated with worse cognitive function in older men [38]. In the Chinese Longitudinal Healthy Longevity Survey, the authors found that air pollution, measured by an index of particulate and gas concentrations, increased the odds of disability in activities of daily living, cognitive impairment, and health deficits [55]. Finally in a study of older women higher levels of long term exposure to PM2.5 and coarse particles were associated with significantly faster cognitive decline [56].

Air pollution can produce its adverse effects in the central nervous system (CNS), through a variety of cellular and molecular mechanisms [57]. Some hypotheses have been suggested to explain these observed associations. One hypothesis is that the presence of particles in the brain due to the migration of particles from the nose to the brain, can causes neurological disorders. An alternative hypothesis is that ambient particle inhalation has a primary effect on the vasculature in the central nervous system (CNS), resulting in subsequent impairment. Particles have been shown to translocate from the nose up the olfactory nerve into the brain, including the striatum frontal cortex, and cerebellum [58, 59]. This in turn is associated with increased brain inflammatory responses [35, 60] and changes in neurotransmitter levels [61]. In humans, diesel exhaust exposure has been shown to alter EEG responses, with patterns indicative of cortical stress [62]. In polluted areas of Mexico City, dogs had more prefrontal lesions, neuro-inflammation, gliosis, and particle deposition. In these polluted areas, brain MRI’s of children had more prefrontal lesions; autopsy studies of accident victims showed upregulation of cyclooxygenase-2 and CD14 [63–65].

Wellenius and co-authors [33] evaluated the association between PM2.5 and cerebrovascular hemodynamics in a cohort of older adults. The authors found that exposure to PM2.5 was associated with higher resting cerebrovascular resistance and lower cerebral blood flow velocity, suggesting that alterations in cerebrovascular hemodynamics may underlie the increased risk of particle-related acute cerebrovascular events.

Another component of vascular function is arterial stiffness; stiffening of the arteries is a process associated with aging and cardiovascular risk factors. In a recent paper Metha and co-authors [34], in a cohort of elderly men in the Boston area, found that short-term changes in air pollution were associated with augmentation index and augmentation pressure, correlates of arterial stiffness, supporting the hypothesis that exposure to air pollution may affect vascular function.

Therefore emerging evidence also suggests that possible biological mechanisms through which pollution can affect neurological disease are air pollution-induced neuro inflammation, oxidative stress, cerebrovascular dysfunction, and systemic inflammation. A better understanding of the mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health [32, 57].

We also found a significant PM2.5 effect in subjects with primary hospitalization for diabetes and in subjects with a previous admission for diabetes, which is higher (although not statistically significantly higher) than the mortality risk in subjects without any of the specified pre-existing conditions. Previous epidemiological studies suggested that people with a hospitalization for diabetes are vulnerable to cardiovascular health effects associated with exposure to particle air pollution. In a 2002 study of 4 US communities we found that diabetics have double the risk of a PM10-associated cardiovascular admission compared with non-diabetics [40]. Similarly, we estimated a 2.0-fold higher mortality risk associated with PM10 exposure for diabetics than for controls in a 2004 case-crossover study [41]. Likewise, PM10 effects on mortality were stronger in diabetics than in non-diabetics in 9 Italian communities [42]. O’Neill and co-authors in two studies examined Boston residents with type 2 diabetes. In one of the study [43] the authors found a positive association between air pollution and inflammatory markers as ICAM-1, VCAM-1 and vWF, suggesting that inflammatory mechanisms may explain the increased risk of air pollution-associated cardiovascular events among persons with diabetes. In the other study the authors found associations between air pollution and endothelium-dependent and -independent vascular reactivity measures [20]. Our results are not directly comparable to these previously published, but we also found increased mortality and hospitalizations risks in diabetics.

Similarly, studies have shown that air pollution is capable of causing these same physiological responses [15, 37]. Some studies have suggested that PM may be associated with reduced heart rate variability [66–70], and increased C-reactive protein [24, 25]. PM2.5 and PM2.5 components have also been shown to increase oxidative stress, including in the heart [24, 26–28], to decrease plaque stability [29, 30], and to increase atherosclerosis [31]. Therefore it is plausible for air pollution to be a factor in developing diabetes [71].

Among the limitations of the study, we measure “susceptibility” by a previous hospitalization as one of the diagnosis in a list of diseases. However, this clearly results in misclassification of the effect modifier, as people in our study population may have diabetes or dementia without a previous admission, or without it being noted in that admission. We also do not include Medicare participants in managed care because their care is paid for by capitation, and hence no specific events are reported to Medicare. This may limit generalization of these results. Another limitation though is due to Medicare reporting only the date of death and not the cause of death.

Conclusions

In this multi-city study we found that short-term exposure to fine particles increased the risk of hospitalizations for Parkinson’s disease and diabetes and of all-cause mortality in Medicare enrollees. The associations persist in the mortality risk of subpopulations of Medicare patients with neurological disease and diabetes hospitalizations prior to death, even though these are not significantly different than the mortality risk among then Medicare enrollees that were never hospitalized for any of these diseases.

The same biological responses thought to effect cardiovascular disease through air pollution-mediated systemic oxidative stress, inflammation, and cerebrovascular dysfunction could also be relevant for diabetes and neurodegenerative diseases. Therefore these results give additional insight into the mechanisms by which particles may affect the brain. More studies are needed to understand the association between exposure and the risk of neurodegenerative diseases development, in order to develop preventative strategies, and improve air quality to reduce the burden of neurological morbidity and mortality.

Abbreviations

PM2.5 :

Fine particulate air matter with aerodynamic diameter less than 2.5 microns

NO2 :

Nitrogen dioxide

MI:

Myocardial Infarction

CI:

Confidence Interval

MEDPAR:

Medicare Provider Analysis and Review

ICD-9:

International Classification of Diseases, Ninth Revision.

AD:

Alzheimer’s disease

MS:

Multiple sclerosis.

References

  1. Zanobetti A, Schwartz J: The effect of fine and coarse particulate air pollution on mortality: a national analysis. Env Heal Perspect. 2009, 117: 898-903. 10.1289/ehp.0800108.

    Article  Google Scholar 

  2. Katsouyanni K, Samet JM, Anderson HR, Atkinson R, Le Tertre A, Medina S, Samoli E, Touloumi G, Burnett RT, Krewski D, Ramsay T, Dominici F, Peng RD, Schwartz J, Zanobetti A: Air pollution and health: a European and North American approach (APHENA). Res Rep Heal Eff Inst. 2009, 142: 5-90.

    CAS  Google Scholar 

  3. Eftim SE, Samet JM, Janes H, McDermott A, Dominici F: Fine particulate matter and mortality: a comparison of the six cities and American Cancer Society cohorts with a medicare cohort. Epidemiology. 2008, 19: 209-216. 10.1097/EDE.0b013e3181632c09.

    Article  Google Scholar 

  4. Katsouyanni K, Zmirou D, Spix C, Sunyer J, Schouten JP, Ponka A, Anderson HR, Le Moullec Y, Wojtyniak B, Vigotti MA, Bacharova L: Short-term effects of air pollution on health: a European approach using epidemiological time-series data. The APHEA project: background, objectives, design. Eur Respir J. 1995, 8: 1030-1038.

    CAS  Google Scholar 

  5. Dominici F, Samet J, Zeger S: Combining evidence on air pollution and daily mortality from the twenty largest US cities: a hierarchical modeling strategy (with discussion). J R Stat Soc Ser A. 2000, 163: 263-302. 10.1111/1467-985X.00170.

    Article  Google Scholar 

  6. Zanobetti A, Schwartz J: The effect of particulate air pollution on emergency admissions for myocardial infarction: a multicity case-crossover analysis. Env Heal Perspect. 2005, 113: 978-982. 10.1289/ehp.7550.

    Article  Google Scholar 

  7. Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM: Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. Jama. 2006, 295: 1127-1134. 10.1001/jama.295.10.1127.

    Article  CAS  Google Scholar 

  8. Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F: Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. Jama. 2008, 299: 2172-2179. 10.1001/jama.299.18.2172.

    Article  CAS  Google Scholar 

  9. Zeger SL, Dominici F, McDermott A, Samet JM: Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000–2005). Env Heal Perspect. 2008, 116: 1614-1619. 10.1289/ehp.11449.

    Article  Google Scholar 

  10. Franklin M, Zeka A, Schwartz J: Association between PM2.5 and all-cause and specific-cause mortality in 27 US communities. J Expo Sci Env Epidemiol. 2007, 17: 279-287. 10.1038/sj.jes.7500530.

    Article  CAS  Google Scholar 

  11. Lokken RP, Wellenius GA, Coull BA, Burger MR, Schlaug G, Suh HH, Mittleman MA: Air pollution and risk of stroke: underestimation of effect due to misclassification of time of event onset. Epidemiology. 2009, 20: 137-142. 10.1097/EDE.0b013e31818ef34a.

    Article  Google Scholar 

  12. Wellenius GA, Schwartz J, Mittleman MA: Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiaries. Stroke. 2005, 36: 2549-2553. 10.1161/01.STR.0000189687.78760.47.

    Article  CAS  Google Scholar 

  13. Le Tertre A, Medina S, Samoli E, Forsberg B, Michelozzi P, Boumghar A, Vonk JM, Bellini A, Atkinson R, Ayres JG, Sunyer J, Schwartz J, Katsouyanni K: Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities. J Epidemiol Community Heal. 2002, 56: 773-779. 10.1136/jech.56.10.773.

    Article  CAS  Google Scholar 

  14. Chan CC, Chuang KJ, Chien LC, Chen WJ, Chang WT: Urban air pollution and emergency admissions for cerebrovascular diseases in Taipei, Taiwan. Eur Hear J. 2006, 27: 1238-1244.

    Article  CAS  Google Scholar 

  15. Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD: Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010, 121: 2331-2378. 10.1161/CIR.0b013e3181dbece1.

    Article  CAS  Google Scholar 

  16. Hong YC, Lee JT, Kim H, Ha EH, Schwartz J, Christiani DC: Effects of air pollutants on acute stroke mortality. Env Heal Perspect. 2002, 110: 187-191. 10.1289/ehp.02110187.

    Article  CAS  Google Scholar 

  17. Zanobetti A, Canner MJ, Stone PH, Schwartz J, Sher D, Eagan-Bengston E, Gates KA, Hartley LH, Suh H, Gold DR: Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation. 2004, 110: 2184-2189. 10.1161/01.CIR.0000143831.33243.D8.

    Article  Google Scholar 

  18. Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR: Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environ Health Perspect. 2012, 120: 241-246.

    Article  CAS  Google Scholar 

  19. Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff DC, Kaufman JD, O’Neill MS: Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA). Env Heal Perspect. 2008, 116: 486-491. 10.1289/ehp.116-a486.

    Article  Google Scholar 

  20. O’Neill MS, Veves A, Zanobetti A, Sarnat JA, Gold DR, Economides PA, Horton ES, Schwartz J: Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation. 2005, 111: 2913-2920. 10.1161/CIRCULATIONAHA.104.517110.

    Article  Google Scholar 

  21. Schneider A, Neas L, Herbst MC, Case M, Williams RW, Cascio W, Hinderliter A, Holguin F, Buse JB, Dungan K, Styner M, Peters A, Devlin RB: Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Env Heal Perspect. 2008, 116: 1666-1674. 10.1289/ehp.11666.

    Article  CAS  Google Scholar 

  22. Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J, Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA, Rajagopalan S, Brook JR: Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension. 2009, 54: 659-667. 10.1161/HYPERTENSIONAHA.109.130237.

    Article  CAS  Google Scholar 

  23. Briet M, Collin C, Laurent S, Tan A, Azizi M, Agharazii M, Jeunemaitre X, Alhenc-Gelas F, Boutouyrie P: Endothelial function and chronic exposure to air pollution in normal male subjects. Hypertension. 2007, 50: 970-976. 10.1161/HYPERTENSIONAHA.107.095844.

    Article  CAS  Google Scholar 

  24. Brook RD, Brook JR, Rajagopalan S: Air pollution: the “Heart” of the problem. Curr Hypertens Reports. 2003, 5: 32-39. 10.1007/s11906-003-0008-y.

    Article  Google Scholar 

  25. Peters A, Frohlich M, Doring A, Immervoll T, Wichmann HE, Hutchinson WL, Pepys MB, Koenig W: Particulate air pollution is associated with an acute phase response in men; results from the MONICA-Augsburg Study. Eur Hear J. 2001, 22: 1198-1204. 10.1053/euhj.2000.2483.

    Article  CAS  Google Scholar 

  26. Bouthillier L, Vincent R, Goegan P, Adamson IY, Bjarnason S, Stewart M, Guenette J, Potvin M, Kumarathasan P: Acute effects of inhaled urban particles and ozone: lung morphology, macrophage activity, and plasma endothelin-1. Am J Pathol. 1998, 153: 1873-1884. 10.1016/S0002-9440(10)65701-X.

    Article  CAS  Google Scholar 

  27. Dhalla NS, Temsah RM, Netticadan T: Role of oxidative stress in cardiovascular diseases. J Hypertens. 2000, 18: 655-673. 10.1097/00004872-200018060-00002.

    Article  CAS  Google Scholar 

  28. Sorensen M, Daneshvar B, Hansen M, Dragsted LO, Hertel O, Knudsen L, Loft S: Personal PM2.5 exposure and markers of oxidative stress in blood. Environ Heal Perspect. 2003, 111: 161-166.

    Article  Google Scholar 

  29. Muller JE, Abela GS, Nesto RW, Tofler GH: Triggers, acute risk factors and vulnerable plaques: the lexicon of a new frontier. J Am Coll Cardiol. 1994, 23: 809-813. 10.1016/0735-1097(94)90772-2.

    Article  CAS  Google Scholar 

  30. Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF: Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol. 2002, 39: 935-942. 10.1016/S0735-1097(02)01715-1.

    Article  CAS  Google Scholar 

  31. Kunzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, Thomas D, Peters J, Hodis HN: Ambient air pollution and atherosclerosis in Los Angeles. Env Heal Perspect. 2005, 113: 201-206.

    Article  CAS  Google Scholar 

  32. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S: Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011, 42: 2672-2713. 10.1161/STR.0b013e3182299496.

    Article  Google Scholar 

  33. Wellenius GA, Boyle LD, Wilker EH, Sorond FA, Coull BA, Koutrakis P, Mittleman MA, Lipsitz LA: Ambient fine particulate matter alters cerebral hemodynamics in the elderly. Stroke. 2013, 44: 1532-1536. 10.1161/STROKEAHA.111.000395.

    Article  CAS  Google Scholar 

  34. Mehta AJ, Zanobetti A, Koutrakis P, Mittleman MA, Sparrow D, Vokonas P, Schwartz J: Associations Between Short-term Changes in Air Pollution and Correlates of Arterial Stiffness: The Normative Aging Study, 2007–2011. Am J Epidemiol. 2014, 179: 192-199. 10.1093/aje/kwt271.

    Article  Google Scholar 

  35. Campbell A, Oldham M, Becaria A, Bondy SC, Meacher D, Sioutas C, Misra C, Mendez LB, Kleinman M: Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology. 2005, 26: 133-140. 10.1016/j.neuro.2004.08.003.

    Article  CAS  Google Scholar 

  36. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O’Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I: Inflammation and Alzheimer’s disease. Neurobiol Aging. 2000, 21: 383-421. 10.1016/S0197-4580(00)00124-X.

    Article  CAS  Google Scholar 

  37. Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, Luepker R, Mittleman M, Samet J, Smith SC, Tager I: Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation. 2004, 109: 2655-2671. 10.1161/01.CIR.0000128587.30041.C8.

    Article  Google Scholar 

  38. Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro A, Schwartz J: Traffic-related air pollution and cognitive function in a cohort of older men. Env Heal Perspect. 2011, 119: 682-687.

    Article  CAS  Google Scholar 

  39. Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F: Exposure to particulate air pollution and cognitive decline in older women. Arch Intern Med. 2012, 172: 219-227. 10.1001/archinternmed.2011.683.

    Article  Google Scholar 

  40. Zanobetti A, Schwartz J: Cardiovascular damage by airborne particles: are diabetics more susceptible?. Epidemiology. 2002, 13: 588-592. 10.1097/00001648-200209000-00016.

    Article  Google Scholar 

  41. Bateson TF, Schwartz J: Who is sensitive to the effects of particulate air pollution on mortality? A case-crossover analysis of effect modifiers. Epidemiology. 2004, 15: 143-149. 10.1097/01.ede.0000112210.68754.fa.

    Article  Google Scholar 

  42. Forastiere F, Stafoggia M, Berti G, Bisanti L, Cernigliaro A, Chiusolo M, Mallone S, Miglio R, Pandolfi P, Rognoni M, Serinelli M, Tessari R, Vigotti M, Perucci CA: Particulate matter and daily mortality: a case-crossover analysis of individual effect modifiers. Epidemiology. 2008, 19: 571-580. 10.1097/EDE.0b013e3181761f8a.

    Article  Google Scholar 

  43. O’Neill MS, Veves A, Sarnat JA, Zanobetti A, Gold DR, Economides PA, Horton ES, Schwartz J: Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Env Med. 2007, 64: 373-379.

    Article  Google Scholar 

  44. Pop-Busui R: Cardiac autonomic neuropathy in diabetes: a clinical perspective. Diabetes Care. 2010, 33: 434-441. 10.2337/dc09-1294.

    Article  Google Scholar 

  45. Ribeiro-Oliveira A, Nogueira AI, Pereira RM, Boas WW, Dos Santos RA, Simoes e Silva AC: The renin-angiotensin system and diabetes: an update. Vasc Health Risk Manag. 2008, 4: 787-803.

    CAS  Google Scholar 

  46. Wellenius GA, Mittleman MA: Disparities in myocardial infarction case fatality rates among the elderly: the 20-year Medicare experience. Am Hear J. 2008, 156: 483-490. 10.1016/j.ahj.2008.04.009.

    Article  Google Scholar 

  47. Schwartz J: Assessing confounding, effect modification, and thresholds in the association between ambient particles and daily deaths. Env Heal Perspect. 2000, 108: 563-568.

    Article  CAS  Google Scholar 

  48. Zanobetti A, Schwartz J, Dockery DW: Airborne particles are a risk factor for hospital admissions for heart and lung disease. Env Heal Perspect. 2000, 108: 1071-1077. 10.1289/ehp.001081071.

    Article  CAS  Google Scholar 

  49. Maclure M: The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991, 133: 144-153.

    CAS  Google Scholar 

  50. Bateson TF, Schwartz J: Control for seasonal variation and time trend in case-crossover studies of acute effects of environmental exposures. Epidemiology. 1999, 10: 539-544. 10.1097/00001648-199909000-00013.

    Article  CAS  Google Scholar 

  51. Bateson TF, Schwartz J: Selection bias and confounding in case-crossover analyses of environmental time-series data. Epidemiology. 2001, 12: 654-661. 10.1097/00001648-200111000-00013.

    Article  CAS  Google Scholar 

  52. Schenker N, Gentleman JF: On Judging the Significance of Differences by Examining the Overlap Between Confidence Intervals. Am Stat. 2001, 55: 182-186. 10.1198/000313001317097960.

    Article  Google Scholar 

  53. Berkey CS, Hoaglin DC, Antczak-Bouckoms A, Mosteller F, Colditz GA: Meta-analysis of multiple outcomes by regression with random effects. Stat Med. 1998, 17: 2537-2550. 10.1002/(SICI)1097-0258(19981130)17:22<2537::AID-SIM953>3.0.CO;2-C.

    Article  CAS  Google Scholar 

  54. Ranft U, Schikowski T, Sugiri D, Krutmann J, Krämer U: Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res. 2009, 109: 1004-1011. 10.1016/j.envres.2009.08.003.

    Article  CAS  Google Scholar 

  55. Zeng Y, Gu D, Purser J, Hoenig H, Christakis N: Associations of environmental factors with elderly health and mortality in China. Am J Public Health. 2010, 100: 298-305. 10.2105/AJPH.2008.154971.

    Article  Google Scholar 

  56. Weuve J, Korrick SA, Weisskopf MGA, Ryan LM, Schwartz J, Nie H, Grodstein F, Hu H: Cumulative exposure to lead in relation to cognitive function in older women. Env Heal Perspect. 2009, 117: 574-580. 10.1289/ehp.11846.

    Article  CAS  Google Scholar 

  57. Genc S, Zadeoglulari Z, Fuss SH, Genc K: The adverse effects of air pollution on the nervous system. J Toxicol. 2012, 2012: 1-23.

    Article  Google Scholar 

  58. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G: Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Env Heal Perspect. 2006, 114: 1172-1178. 10.1289/ehp.9030.

    Article  CAS  Google Scholar 

  59. Wang B, Feng WY, Wang M, Shi JW, Zhang F, Ouyang H, Zhao YL, Chai ZF, Huang YY, Xie YN, Wang HF, Wang J: Transport of intranasally instilled fine Fe2O3 particles into the brain: micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res. 2007, 118: 233-243. 10.1007/s12011-007-0028-6.

    Article  CAS  Google Scholar 

  60. Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Li H, Bondy SC: Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicol Lett. 2008, 178: 127-130. 10.1016/j.toxlet.2008.03.001.

    Article  CAS  Google Scholar 

  61. Tin Tin Win S, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H: Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure. Toxicol Appl Pharmacol. 2008, 226: 192-198. 10.1016/j.taap.2007.09.009.

    Article  Google Scholar 

  62. Cruts B, van Etten L, Tornqvist H, Blomberg A, Sandstrom T, Mills NL, Borm PJ: Exposure to diesel exhaust induces changes in EEG in human volunteers. Part Fibre Toxicol. 2008, 5: 4-10.1186/1743-8977-5-4.

    Article  Google Scholar 

  63. Calderon-Garciduenas L, Mora-Tiscareno A, Ontiveros E, Gomez-Garza G, Barragan-Mejia G, Broadway J, Chapman S, Valencia-Salazar G, Jewells V, Maronpot RR, Henriquez-Roldan C, Perez-Guille B, Torres-Jardon R, Herrit L, Brooks D, Osnaya-Brizuela N, Monroy ME, Gonzalez-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Solt AC, Engle RW: Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn. 2008, 68: 117-127. 10.1016/j.bandc.2008.04.008.

    Article  Google Scholar 

  64. Calderon-Garciduenas L, Reed W, Maronpot RR, Henriquez-Roldan C, Delgado-Chavez R, Calderon-Garciduenas A, Dragustinovis I, Franco-Lira M, Aragon-Flores M, Solt AC, Altenburg M, Torres-Jardon R, Swenberg JA: Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution. Toxicol Pathol. 2004, 32: 650-658. 10.1080/01926230490520232.

    Article  Google Scholar 

  65. Calderon-Garciduenas L, Solt AC, Henriquez-Roldan C, Torres-Jardon R, Nuse B, Herritt L, Villarreal-Calderon R, Osnaya N, Stone I, Garcia R, Brooks DM, Gonzalez-Maciel A, Reynoso-Robles R, Delgado-Chavez R, Reed W: Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood–brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and youn. Toxicol Pathol. 2008, 36: 289-310. 10.1177/0192623307313011.

    Article  CAS  Google Scholar 

  66. Creason J, Neas L, Walsh D, Williams R, Sheldon L, Liao D, Shy C: Particulate matter and heart rate variability among elderly retirees: the Baltimore 1998 PM study. J Expo Anal Env Epidemiol. 2001, 11: 116-122. 10.1038/sj.jea.7500154.

    Article  CAS  Google Scholar 

  67. Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, Allen G, Verrier M, Cherry R, Verrier R: Ambient pollution and heart rate variability. Circulation. 2000, 101: 1267-1273. 10.1161/01.CIR.101.11.1267.

    Article  CAS  Google Scholar 

  68. Liao D, Creason J, Shy C, Williams R, Watts R, Zweidinger R: Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Env Heal Perspect. 1999, 107: 521-525. 10.1289/ehp.99107521.

    Article  CAS  Google Scholar 

  69. Baccarelli A, Cassano PA, Litonjua A, Park SK, Suh H, Sparrow D, Vokonas P, Schwartz J: Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008, 117: 1802-1809. 10.1161/CIRCULATIONAHA.107.726067.

    Article  Google Scholar 

  70. Pope CA, Hansen ML, Long RW, Nielsen KR, Eatough NL, Wilson WE, Eatough DJ: Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Env Heal Perspect. 2004, 112: 339-345. 10.1289/ehp.112-a339.

    Article  Google Scholar 

  71. Brook RD, Jerrett M, Brook JR, Bard RL, Finkelstein MM: The relationship between diabetes mellitus and traffic-related air pollution. J Occup Env Med. 2008, 50: 32-38. 10.1097/JOM.0b013e31815dba70.

    Article  CAS  Google Scholar 

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Acknowledgements

This publication was developed under a USEPA STAR Research Assistance Agreement No. RD-834900 and was also made possible by USEPA grant RD 83479801, and R834894 awarded by the U.S. Environmental Protection Agency. Its contents are solely the responsibility of the grantee and do not necessarily represent the official views of the USEPA. Further, USEPA does not endorse the purchase of any commercial products or services mentioned in the publication.

The project was also supported by NIEHS ES0002, and R01ES012054 from the National Institute of Environmental Health Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Environmental Health Sciences of the National Institutes of Health.

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  1. Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA

    Antonella Zanobetti & Joel D Schwartz

  2. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA

    Francesca Dominici & Yun Wang

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  1. Antonella Zanobetti
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  2. Francesca Dominici
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Authors’ contributions

AZ: designed the study and conducted the analysis, interpreted the data, drafted the paper, and approved the final version. FD: obtained the data, interpreted the data, revised the paper critically for important intellectual content, and approved the final version. YW: created the dataset, conducted quality assurance and control, revised the paper, and approved the final version. JS: designed the study, interpreted the data, revised the paper, and approved the final version.

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Additional file 1: Table S1 and Table S2: A National analysis of the short term effect of PM2.5 on hospitalizations and mortality in subjects with diabetes and neurological disorders. (DOCX 58 KB)

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Zanobetti, A., Dominici, F., Wang, Y. et al. A national case-crossover analysis of the short-term effect of PM2.5 on hospitalizations and mortality in subjects with diabetes and neurological disorders. Environ Health 13, 38 (2014). https://doi.org/10.1186/1476-069X-13-38

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Keywords

Environmental Health

ISSN: 1476-069X