Table 7

Breast cancer odds ratios for cumulative exposure accruing in time-windows reflecting reproductive status, by conditional multiple logistic regression
Parameter
Window OR (95% CI) Wald P
Cumulative Exposure1I
< menarche 1.037 (0.89-1.21)
menarche-first pregnancy 1.018 (0.98-1.06)
first pregnancy – menopause 1.036 (1.01-1.06) 0.012
menopause - 1.012 (0.97-1.06)
Cumulative Exposure2II
< menarche 1.003 (0.85-1.18)
menarche-first pregnancy 1.037 (0.98-1.09) 0.18
first pregnancy – menopause 1.050 (1.01-1.09) 0.0072
menopause - 1.018 (0.97-1.07)
Selected cumulative exposures2,3,4
Farming
< menarche 1.054 (0.88-1.26)
menarche-first pregnancy 0.997 (0.93-1.07)
first pregnancy – menopause 1.046 (0.98-1.12) 0.19
menopause - 1.054 (0.96-1.16)
Bars, gambling
menarche-first pregnancy 1.022 (0.81-1.29)
first pregnancy – menopause 1.141 (0.98-1.33) 0.092
menopause - 1.039 (0.82-1.32)
Metalworking
menarche-first pregnancy 1.161 (0.96-1.40) 0.12
first pregnancy – menopause 1.064 (0.97-1.16) 0.17
menopause - 1.020 (0.92-1.13)
Auto industry: plastics
menarche-first pregnancy 1.297 (1.05-1.61) 0.018
first pregnancy – menopause 1.104 (1.01-1.20) 0.023
menopause - 1.044 (0.92-1.19)
Canning
menarche-first pregnancy 1.262 (0.96-1.66) 0.095
first pregnancy – menopause 1.079 (0.96-1.22)
menopause - 1.041 (0.88-1.24)

All three models include reproductive, demographic risk factors as in Table 4 and employment duration; matching on age in 3-year intervals.

OR for cumulative exposure evaluated at 1.0 year in time-window in high-exposed jobs (lagged 5 year).

1. cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 1, 2, as rating-year.

2. cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 1, 10, as rating-year.

3. model includes all major sector exposures;

4. no cases/controls with non-farm exposure in window: < menarche.

Brophy et al.

Brophy et al. Environmental Health 2012 11:87   doi:10.1186/1476-069X-11-87

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