Table 6

Breast cancer odds ratios (matched analysis) with cumulative exposures, in major sectors and for derived hypotheses, and interactions with prior agricultural work, by conditional logistic regression
Model/Parameter OR (95% CI) Wald P
Model 1
  Cumulative Exposure1 I (lagged 5 year) 1.29 (1.10-1.51) 0.0017
Model 2
  Cumulative Exposure2 II (lagged 5 year) 1.42 (1.18-1.73) 0.0003
Model 3
Farming 1.34 (1.03-1.74) 0.031
Non-plastic light mfg 0.83 (0.29-2.37) 0.73
Chemical, petrochemical 2.15 (0.0->100) 0.82
Plastics 2.43 (1.39-4.22) 0.0018
Metalworking 1.73 (1.02-2.92) 0.041
Transport 0.84 (0.28-2.52) 0.76
Beauty care/laundry/dry cleaning 1.02 (0.72-1.43) 0.92
Bars/gambling 2.20 (0.91-5.29) 0.078
Model 4
Farming: all 1.36 (1.01-1.82) 0.044
Farming: corn (since 1978) 0.76 (0.09-6.69) 0.80
Farming: greenhouse workers 1.04 (0.38-2.83) 0.94
Non-plastic light mfg 0.87 (0.30-2.50) 0.80
Chemical, petrochemical 1.47 (0.0->100) 0.91
Transport 0.80 (0.25-2.54) 0.71
Beauty care/laundry/dry cleaning 1.02 (0.72-1.43) 0.92
Bars/gambling 2.28 (0.94-5.53) 0.068
Auto industry: plastics 2.68 (1.47-4.88) 0.0013
Auto industry: small enterprises 2.48 (1.00-6.10) 0.051
Auto industry: large enterprises 1.18 (0.56-2.50) 0.66
Canning 2.35 (1.00-5.53) 0.050
Healthcare workers 1.01 (0.87-1.18) 0.89
Toll booth workers 1.17 (0.44-3.14) 0.76
Model 5
Farming: all 1.35 (1.00-1.82) 0.049
Farming: corn (since 1978) 0.64 (0.07-5.78) 0.69
Farming: greenhouse workers 0.95 (0.35-2.60) 0.92
Non-plastic light mfg 0.86 (0.30-2.49) 0.78
Chemical, petrochemical 1.56 (0.0->100) 0.90
Metalworking 1.71 (0.99-2.95) 0.055
Metalworkingl… IpAg 1.04 (0.89-1.21) 0.64
Transport 0.82 (0.27-2.55) 0.74
Beauty care/laundry/dry cleaning 1.03 (0.73-1.45) 0.87
Bars, gambling 1.79 (0.67-4.73) 0.24
Bars, gambling … IpAg 2.38 (0.58-9.79) 0.23
Auto industry: plastics 2.41 (1.31-4.44) 0.0048
Auto plastics… IpAg 2.31 (0.53-9.98) 0.26
Canning 1.90 (0.72-4.99) 0.19
Canning … IpAg 1.14 (0.83-1.56) 0.43
Healthcare workers 1.05 (0.89-1.24) 0.54
Healthcare… IpAg 0.96 (0.91-1.02) 0.20
Toll booth workers 1.17 (0.43-3.13) 0.76

All five models include reproductive, demographic risk factors as in Table 4 and employment duration terms; IpAg, interaction with farming: cumulative (sector rating × prior cum. exposure in agriculture).

Odds ratios (OR) evaluated at 10 years in high-exposed jobs (lagged 5 year) or, for interactions, at 10 years in high-exposed jobs and 1 year in prior high-exposed farm work; matching on age in 3-year intervals; for including employment duration terms: χ2 (2df) =10.9, p=0.025 (Model 4).

1. cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 1, 2, as rating-year.

2. cumulative exposure on transformed ratings: 1 (low), 2 (moderate), 3 (high) → 0, 1, 10, as rating-year, except bars/gambling and toll booth workers (maximum rating = 1; no jobs rated high).

Brophy et al.

Brophy et al. Environmental Health 2012 11:87   doi:10.1186/1476-069X-11-87

Open Data