Table 6 |
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|
Association between breast cancer and high cumulative PCE exposure: comparison of various cut points |
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|
Latency period (years) |
Prior Analysis >90th Percentile |
Current Analysis >90th Percentile |
Current Analysis Smoothing |
|
|
|||
|
0 |
|||
|
RDD |
41.8 |
19.5 |
35 |
|
Case/control |
18/21 |
56/64 |
26/32 |
|
COR (95% CI) |
1.3 (0.7-2.4) |
1.2 (0.8-1.8) |
1.1 (0.7-1.9) |
|
AOR (95% CI) |
1.3 (0.7-2.6) |
1.3 (0.9-1.9) |
1.3 (0.7-2.3) |
|
5 |
|||
|
RDD |
41.7 |
20.6 |
35 |
|
Case/control |
17/16 |
53/55 |
24/30 |
|
COR (95% CI) |
1.6 (0.8-3.1) |
1.3 (0.9-2.0) |
1.1 (0.6-1.9) |
|
AOR (95% CI) |
1.5 (0.7-3.0) |
1.4 (0.9-2.1) |
1.3 (0.7-2.3) |
|
7 |
|||
|
RDD |
40.9 |
19.0 |
35 |
|
Case/control |
17/13 |
51/49 |
23/25 |
|
COR (95% CI) |
1.9 (0.9-4.0) |
1.5 (1.0-2.2) |
1.3 (0.7-2.3) |
|
AOR (95% CI) |
1.7 (0.8-3.6) |
1.4 (0.9-2.2) |
1.4 (0.7-2.5) |
|
9 |
|||
|
RDD |
38.4 |
17.4 |
35 |
|
Case/control |
16/11 |
47/43 |
21/19 |
|
COR (95% CI) |
2.1 (1.0-4.6) |
1.5 (1.0-2.4) |
1.6 (0.8-3.0) |
|
AOR (95% CI) |
1.9 (0.8-4.4) |
1.4 (0.9-2.2) |
1.6 (0.8-3.0) |
|
11 |
|||
|
RDD |
37.3 |
16.1 |
35 |
|
Case/control |
12/8 |
40/37 |
17/14 |
|
COR (95% CI) |
2.2 (0.9-5.4) |
1.5 (1.0-2.5) |
1.8 (0.8-3.6) |
|
AOR (95% CI) |
1.8 (0.7-4.8) |
1.4 (0.9-2.4) |
1.8 (0.8-3.9) |
|
13 |
|||
|
RDD |
36.8 |
12.8 |
35 |
|
Case/control |
8/5 |
37/32 |
13/10 |
|
COR (95% CI) |
2.3 (0.8-7.2) |
1.7 (1.0-2.7) |
1.9 (0.8-4.6) |
|
AOR (95% CI) |
1.7 (0.5-5.2) |
1.5 (0.9-2.5) |
2.0 (0.8-4.8) |
|
15 |
|||
|
RDD |
49.1 |
14.0 |
35 |
|
Case/control |
2/3 |
20/22 |
8/5 |
|
COR (95% CI) |
1.0 (0.2-5.9) |
1.3 (0.7-2.4) |
2.1 (0.7-6.6) |
|
AOR (95% CI) |
- |
1.0 (0.5-1.9) |
1.8 (0.6-5.6) |
|
17 |
|||
|
RDD |
40.6 |
11.4 |
35 |
|
Case/control |
1/2 |
18/14 |
4/5 |
|
COR (95% CI) |
0.7 (0.1-8.1) |
1.7 (0.8-3.5) |
1.1 (0.3-4.0) |
|
AOR (95% CI) |
- |
1.3 (0.6-2.7) |
- |
|
19 |
|||
|
RDD |
169.9 |
9.5 |
35 |
|
Case/control |
0/0 |
9/7 |
0/2 |
|
COR (95% CI) |
- |
1.7 (0.6-4.7) |
- |
|
AOR (95% CI) |
- |
1.3 (0.5-3.6) |
- |
|
|
|||
|
Note: The referent group was comprised of never exposed cases (n = 471) and controls (n = 645). The adjusted analysis controlled for age at diagnosis or index year, vital status at interview, family history of breast cancer, personal history of breast cancer (before current diagnosis or index year), age at first live birth or stillbirth, occupational exposure to PCE, and study of origin. |
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|
Gallagher et al. Environmental Health 2011 10:47 doi:10.1186/1476-069X-10-47 |
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